Publikationen Zink-Finger-Biologie

Tetracyclin-reversible silencing of eukaryotic promoters Deuschle U, Meyer WK, Thiesen HJ 1995 Apr, Mol Cell Biol;PMID: 7891684 SysZNF: the C2H2 zinc finger gene database Ding G, Lorenz P, Kreutzer M, Li Y, Thiesen HJ 2009 Jan, Nucleic Acids Res;PMID:18974185 The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain Peter Lorenz, Felix Steinbeck, Ludwig Krause, Hans-Jürgen Thiesen 2022 Jan 19, Int J Mol Sci, PMID: 35162997

Publikationen Autoimmunerkrankungen

Proteome analysis reveals disease-associated marker proteins to differentiate RA patients from other inflammatory joint diseases with the potential to monitor anti-TNFalpha therapy Susanne Drynda 1, Bruno Ringel, Monika Kekow, Cornelia Kühne, Andreas Drynda, Michael O Glocker, Hans-Jürgen Thiesen, Jörn Kekow 2004, Pathol Res Pract, PMID: 15237925 Rheumatoid arthritis, a complex multifactorial disease: on the way towards individualized medicine Glocker MO, Guthke R, Kekow J, Thiesen HJ 2006 Jan, Med Res Rev; PMID:16283676 Mass spectrometric and peptide chip epitope mapping of rheumatoid arthritis autoantigen RA33 R F El-Kased, C Koy, T Deierling, P Lorenz, Z Qian, Y Li, H-J Thiesen, M O Glocker 2009, Eur J Mass Spectrom, PMID: 19940341 Mass spectrometric and peptide chip characterization of an assembled epitope: analysis of a polyclonal antibody model serum directed against the Sjøgren/systemic lupus erythematosus autoantigen TRIM21 M Al-Majdoub, C Koy, P Lorenz, H-J Thiesen, M O Glocker 2013 Jun, J Mass Spectrom, PMID: 23722955

Publikationen Onkologie

Towards a proteome signature for invasive ductal breast carcinoma derived from label-free nanoscale LC-MS protein expression profiling of tumorous and glandular tissue Claudia Röwer, Johannes P C Vissers, Cornelia Koy, Marc Kipping, Michael Hecker, Toralf Reimer, Bernd Gerber, Hans-Jürgen Thiesen, Michael O Glocker 2009 Dec, Anal Bioanal Chem, PMID: 19876624 Toponostics of invasive ductal breast carcinoma: combination of spatial protein expression imaging and quantitative proteome signature analysis Claudia Röwer, Björn Ziems, Anngret Radtke, Oliver Schmitt, Toralf Reimer, Cornelia Koy, Hans-Jürgen Thiesen, Bernd Gerber, Michael O Glocker 2011 Mar 31, Int J Clin Exp Pathol, PMID: 21738817 Clonality characterization of natural epitope-specific antibodies against the tumor-related antigen topoisomerase IIa by peptide chip and proteome analysis: a pilot study with colorectal carcinoma patient samples Michael Linnebacher, Peter Lorenz, Cornelia Koy, Annika Jahnke, Nadine Born, Felix Steinbeck, Johannes Wollbold, Tobias Latzkow, Hans-Jürgen Thiesen, Michael O Glocker 2012 Apr, Anal Bioanal Chem, PMID: 22349330 Stratification of clear cell renal cell carcinoma (ccRCC) genomes by gene-directed copy number alteration (CAN) analysis Thiesen HJ, Steinbeck F, Maruschke M, Koczan D, Ziems B, Hakenberg OW 2017 May 9, PLoS One, PMID:28486536 Loss of cadherin related family member 5 (CDHR5) expression in clear cell renal cell carcinoma is a prognostic marker of disease progression Felix Marius Bläsius, Sebastian Meller, Carsten Stephan, Klaus Jung, Jörg Ellinger, Michael O Glocker, Hans-Jürgen Thiesen, Yuri Tolkach, Glen Kristiansen 2017 Aug 24, Oncotarget, PMID:29088846

Publikationen Epitope Prediction und Epitope Mapping

Epitope predictions indicate the presence of two distinct types of epitope-antibody-reactivities determined by epitope profiling of intravenous immunoglobulins Lustrek M, Lorenz P, Kreutzer M, Qian Z, Steinbeck F, Wu D, Born N, Ziems B, Hecker M, Blank M, Shoenfeld Y, Cao Z, Glocker MO, Li Y, Fuellen G, Thiesen HJ 2013 Nov 11, PLoS One, PMID: 24244326 Intact Transition Epitope Mapping (ITEM) Yelena Yefremova, Kwabena F M Opuni, Bright D Danquah, Hans-Juergen Thiesen, Michael O Glocker 2017, J Am Soc Mass Spectrom, PMID: 28616748 ITEM-THREE analysis of a monoclonal anti-malaria antibody reveals its assembled epitope on the pf MSP119 antigen Kwabena F M Opuni, Cornelia Koy, Manuela Russ, Maren Reepmeyer, Bright D Danquah, Moritz Weresow, Astrid Alef, Peter Lorenz, Hans-Juergen Thiesen, Michael O Glocker 2020 Oct 30, J Biol Chem, PMID: 32848020 Epitope Fine Mapping by Mass Spectrometry: Investigations of Immune Complexes Consisting of Monoclonal Anti-HpTGEKP Antibody and Zinc Finger Protein Linker Phospho-Hexapeptides Maximilian Scherf, Bright D Danquah, Cornelia Koy, Peter Lorenz, Felix Steinbeck, Andrei Neamtu, Hans-Jürgen Thiesen, Michael O Glocker 2022 Oct 19, Chembiochem, PMID: 35950614

Publikationen Corona

Compared with SARS-CoV2 wild type’s spike protein, the SARS-CoV2 omicron’s receptor binding motif has adopted a more SARS-CoV1 and/or bat/civet-like structure Michael O Glocker, Kwabena F M Opuni, Hans-Juergen Thiesen 2021 Dec 15, bioRxiv The Preprint Server for Biology, From Free Binding Energy Calculations of SARS-CoV-2-Receptor Interactions to Cellular Immune Responses Michael O Glocker, Kwabena F M Opuni, Hans-Juergen Thiesen 2022 Feb 2, Medicina (Kaunas), PMID: 35208550

Publikationen P4 Family Medicine

The IndyMed Preparedness Initiative: A roadmap from Corona, Long COVID, Post-Vac to Chronic Fatigue Syndrome and P4 Family Medicine Hans-Juergen Thiesen 2024, Bookchapter in New COVID-19 Variants, submitted, accepted, publication in progress